Find and compare 4 Star hotels in Medical Center District

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Top Medical Center District 4 Star hotels

Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $119 per night
$119
per night
May 12 - May 13
This hotel features a restaurant, an outdoor pool, and a bar/lounge. WiFi in public areas is free. Valet parking, a 24-hour business center, and a coffee shop are also offered.
Breakfast available
Pool
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $199 per night
$199
per night
Apr 28 - Apr 29
A full-service spa, a 24-hour gym, and a restaurant are all featured at this Mediterranean hotel. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. You'll appreciate the outdoor pool, bar/lounge, and concierge services.
Hot Tub
Pet friendly
The Westin Riverwalk, San Antonio

The Westin Riverwalk, San Antonio

4 out of 5
420 W Market St, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $202 per night
$202
per night
May 19 - May 20
The hotel's outdoor pool, 24-hour gym, and 2 bars/lounges are among the featured amenities. Traveling on business? Take advantage of the business center, express check-out, and valet parking. A restaurant, a 24-hour front desk, and a coffee shop are also provided.
Pet friendly
Breakfast available
Hyatt Regency Hill Country Resort & Spa

Hyatt Regency Hill Country Resort & Spa

4 out of 5
9800 Hyatt Resort Dr, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $270 per night
$270
per night
Apr 28 - Apr 29
This eco-certified hotel features a golf course, free water park access, and a full-service spa. Bring the family and enjoy the lazy river, children's pool, and waterslide. Enjoy the 3 outdoor pools and perks like free WiFi.
Hot Tub
Pet friendly
Grand Hyatt San Antonio River Walk

Grand Hyatt San Antonio River Walk

4 out of 5
600 E Market St, San Antonio, TX
Free Cancellation
The price is $202 per night
$202
per night
Apr 28 - Apr 29
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Families will appreciate the arcade/game room and onsite laundry facilities. Enjoy the 24-hour gym and perks like free WiFi.
Pet friendly
Breakfast available
The St. Anthony, A Luxury Collection Hotel, San Antonio

The St. Anthony, A Luxury Collection Hotel, San Antonio

4.5 out of 5
300 E Travis St, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $215 per night
$215
per night
May 19 - May 20
This hotel features 2 restaurants, an outdoor pool, and a gym. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. Enjoy the a rooftop terrace and visit the 3 bars/lounges and poolside bar for drinks.
Pet friendly
Breakfast available
Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk

4 out of 5
123 Losoya St, San Antonio, TX
Free Cancellation
The price is $179 per night
$179
per night
May 26 - May 27
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. You'll appreciate the 24-hour gym, bar/lounge, and laundry facilities.
Pet friendly
Breakfast available
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $214 per night
$214
per night
May 9 - May 10
A full-service spa, 2 restaurants, and an outdoor pool are all featured at this smoke-free hotel. Traveling on business? Take advantage of the free WiFi in public areas, express check-in, and valet parking. Enjoy the 24-hour gym and perks like a free area shuttle.
Pet friendly
Breakfast available
Canopy by Hilton San Antonio Riverwalk

Canopy by Hilton San Antonio Riverwalk

4 out of 5
123 N. Saint Marys St., San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $191 per night
$191
per night
May 12 - May 13
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public areas, and valet parking. A terrace, a computer station, and dry cleaning are also on offer.
Pet friendly
Breakfast available
La Cantera Resort & Spa

La Cantera Resort & Spa

4 out of 5
16641 La Cantera Pkwy, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $409 per night
$409
per night
May 15 - May 16
This traditional hotel features a golf course, a full-service spa, and 5 restaurants. There's fun for all ages with a children's pool and a waterslide, and supervised childcare is an added bonus. Traveling on business? Take advantage of the business center, express check-out, and valet parking.
The Westin San Antonio North

The Westin San Antonio North

4 out of 5
9821 Colonnade Blvd, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $119 per night
$119
per night
May 12 - May 13
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the indoor pool and perks like free self parking.
Hot Tub
Pet friendly
AC Hotel by Marriott San Antonio Riverwalk

AC Hotel by Marriott San Antonio Riverwalk

4 out of 5
111 SOLEDAD STREET, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
The price is $122 per night
$122
per night
May 12 - May 13
This smoke-free hotel's 2 restaurants, 2 bars/lounges, and 24-hour gym are some of the featured amenities. Traveling on business? Take advantage of the business center, free WiFi in public areas, and valet parking. A terrace, a snack bar/deli, and a grocery/convenience store are also on offer.
Pet friendly
Breakfast available
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District hotels essential information

Accommodation
4,239 hotels
Lowest Price
$119
Highest Price
$409
Popular hotels
Riverwalk Plaza, Hotel Contessa, The Westin Riverwalk, San Antonio, Hyatt Regency Hill Country Resort & Spa, Grand Hyatt San Antonio River Walk, The St. Anthony, A Luxury Collection Hotel, San Antonio, Hyatt Regency San Antonio Riverwalk, Omni La Mansion del Rio, Canopy by Hilton San Antonio Riverwalk, La Cantera Resort & Spa, The Westin San Antonio North, AC Hotel by Marriott San Antonio Riverwalk

Recent Medical Center District hotel reviews by fellow wanderers

Hotel Contessa

Hotel Contessa

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Centrally located for Riverwalk activities. We had a corner/river view room so we could see multiple areas of the river. We were there for Fiesta and they had an excellent Mariachi band playing. Friendly staff and fast check in and out. Early and late pool hours. Kuerig coffee machine and bottled water provided as well as a refrigerator. Must have room key to use elevators making it more secure. About $25 to and from airport with Taxi or Uber and we had no wait. "
A verified traveler from Elkhart stayed at Hotel Contessa
Hotel Contessa

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