St. Louis to San Diego Flights (STL-SAN) from $43

Wander Wisely with exceptional service, 24/7 support

Feel at ease with free flight cancellations within 24 hours of booking

Change your flight without a fee on select flights

Selected fares from St. Louis to San Diego

The cheapest prices found with in the last 7 days for return flights were $124 and $43 for one-way flights to San Diego for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Sat, Aug 24 - Tue, Aug 27
STL
Lambert-St. Louis Intl.
SAN
San Diego Intl.
$124 Roundtrip, found 1 day ago
$124
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Sat, Aug 24 from Lambert-St. Louis Intl. to San Diego Intl., returning Tue, Aug 27, priced at $124 found 1 day ago
Frontier Airlines
Tue, Jun 4 - Wed, Jun 5
STL
Lambert-St. Louis Intl.
SAN
San Diego Intl.
$136 Roundtrip, found 3 hours ago
$136
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Tue, Jun 4 from Lambert-St. Louis Intl. to San Diego Intl., returning Wed, Jun 5, priced at $136 found 3 hours ago
American Airlines
Fri, Aug 16 - Wed, Aug 21
STL
Lambert-St. Louis Intl.
SAN
San Diego Intl.
$219 Roundtrip, found 6 days ago
$219
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Aug 16 from Lambert-St. Louis Intl. to San Diego Intl., returning Wed, Aug 21, priced at $219 found 6 days ago

Save more with San Diego Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Ramada by Wyndham San Diego Poway Miramar

Ramada by Wyndham San Diego Poway Miramar

2 out of 5
per person
Jun 27 - Jul 2
found 15 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to San Diego (SAN)
Howard Johnson by Wyndham San Diego Sea World

Howard Johnson by Wyndham San Diego Sea World

2 out of 5
per person
Jun 27 - Jul 2
found 15 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to San Diego (SAN)
Days Inn by Wyndham Chula Vista/San Diego

Days Inn by Wyndham Chula Vista/San Diego

2.5 out of 5
per person
Jun 27 - Jul 2
found 15 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to San Diego (SAN)
Sonesta ES Suites San Diego - Rancho Bernardo

Sonesta ES Suites San Diego - Rancho Bernardo

3 out of 5
per person
Jun 27 - Jul 2
found 15 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to San Diego (SAN)
Home2 Suites by Hilton Temecula

Home2 Suites by Hilton Temecula

3 out of 5
per person
Jun 27 - Jul 2
found 15 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to San Diego (SAN)
Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista

3 out of 5
per person
Jun 27 - Jul 2
found 15 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to San Diego (SAN)
Don't see what you're looking for?
See all available trips from St. Louis to San Diego
View all trips