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Hotels near Historic Main Street

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One Block From the Heart of Main Street!!

One Block From the Heart of Main Street!!

St. Charles, MO
0.3 km from Historic Main Street
This vacation home includes a garden and barbecue grills.
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Perfect for your vacation stay in Historic St. Charles! Near Main Street

Perfect for your vacation stay in Historic St. Charles! Near Main Street

St. Charles, MO
0.5 km from Historic Main Street
Located in the center of St. Charles, this family-friendly guesthouse is within a 10-minute walk of Historic Main Street and SSM Health St. Joseph Hospital. Ameristar Casino St. Charles is 1.6 mi (2.5 km) away.
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Clark Brick House w/ Pool - Historic St. Charles

Clark Brick House w/ Pool - Historic St. Charles

St. Charles, MO
0.9 km from Historic Main Street
A garden is available at this vacation home.
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Amazing 1860's Historic Home!

Amazing 1860's Historic Home!

St. Charles, MO
0.5 km from Historic Main Street
This vacation home features a water park and a garden.
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St. Charles 1860's Gem - Sleeps 8!

St. Charles 1860's Gem - Sleeps 8!

St. Charles, MO
0.5 km from Historic Main Street
A garden is available at this vacation home.
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1920's Vintage Home in Historic Saint Charles - Fully Remodeled

1920's Vintage Home in Historic Saint Charles - Fully Remodeled

St. Charles, MO
0.9 km from Historic Main Street
A garden is available at this vacation home.
$86
Country Inn & Suites by Radisson, St. Charles, MO

Country Inn & Suites by Radisson, St. Charles, MO

2.5 out of 5.0 1190 S Main St, St. Charles, MO
4.7/5
(18 Reviews)
1.0 km from Historic Main Street
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like buffet breakfast and free self parking.
$104
Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel

3.0 out of 5.0 1425 South 5th Street, St. Charles, MO
3.6/5
(12 Reviews)
1.3 km from Historic Main Street
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free perks include buffet breakfast, free self parking, and an area shuttle.
$169
Ameristar Casino Resort and Spa (St. Charles)

Ameristar Casino Resort and Spa (St. Charles)

4.5 out of 5.0 1 Ameristar Blvd, St. Charles, MO
3.8/5
(20 Reviews)
1.5 km from Historic Main Street
This luxury hotel features a casino, a full-service spa, and a nightclub. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. 7 restaurants, 2 bars/lounges, and a poolside bar offer an array of options for drinks and a bit to eat.
$99
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

3.0 out of 5.0 380 Mulholland Drive, St. Charles, MO
4.4/5
(14 Reviews)
1.7 km from Historic Main Street
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the 24-hour fitness center and free perks like buffet breakfast and free self parking.
$122
Embassy Suites St. Louis - St. Charles

Embassy Suites St. Louis - St. Charles

3.5 out of 5.0 2 Convention Center Plz, St. Charles, MO
4.5/5
(11 Reviews)
1.6 km from Historic Main Street
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the business center and WiFi in public areas. Enjoy the fitness center and free perks like buffet breakfast and free self parking.
$89
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5.0 777 Casino Center Drive, Maryland Heights, MO
4.2/5
(57 Reviews)
3.0 km from Historic Main Street
This hotel features a casino, a nightclub, and 7 restaurants. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Relax with a drink at one of the 3 bars/lounges and enjoy perks like free self parking.
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Hotels Close to Historic Main Street

Your next vacation is around the corner. The kids are out of school, you and the spouse have two weeks off, and it’s about time to get the heck out of dodge. You must experience the culture and see the sights. Book your stay Historic Main Street hotels with us at Travelocity and enjoy the trip of a lifetime.

Finally, you can stay near the sites you’ve only read about in books. Now they are next door. Start fresh in the morning with the amazing views from your balcony. Then hop on any number of tour buses and take postcard-worthy pictures of the attractions you once thought couldn’t be real, but now you find them through your lens. Hotels near Historic Main Street will offer you the best in prices, activities, amenities, dining, and nightlife.

You may not want to imitate the Griswald’s--that’s been done one too many times—but you do want to have a memorable trip. With Travelocity’s long list of cheap hotels near Historic Main Street, you’re sure to find the perfect place to stay within your preferred budget. We’ll match a lower price and refund the difference. Book now and let us make your next vacation the easiest of your life.


Recent Historic Main Street hotel reviews by fellow wanderers


*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.