Beginning of main content

Get 24/7 travel help, thanks to our Customer First Guarantee

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Featured Southeast Missouri Villas

Get Rates
Villa Next to a Lake 5-hole Golf On-site, Outdoor Pool, Mini Golf + More

Villa Next to a Lake 5-hole Golf On-site, Outdoor Pool, Mini Golf + More

De Soto, MO
A sauna is available at this villa.
 
Map

Southeast Missouri Villa Rentals

Wake up, stretch, and pad across the bedroom to your kitchen. You’ve got a busy day of exploring ahead, and you’ll face it best with a mug of piping hot coffee in your hand. Look out the window at the rising sun and take a deep breath.

This can be your life if you rent a villa in Southeast Missouri. Once upon a time, villas were huge Roman buildings owned by the wealthiest citizens. These days, you can still find palatial villas—but there’s smaller, cozier options to choose from as well.

What makes villas so special? First, they offer you and your travel group privacy and space. After a long day of exploring Southeast Missouri, a villa truly becomes your home away from home. Lay down in one of the bedrooms for a midday catnap, then make use of the fully stocked kitchen and craft a culinary masterpiece to serve up on the private patio. Your companions will be talking about it for years to come.

Do you want to really treat yourself during your time in Southeast Missouri? Go for it. Luxury villas will make you feel like a million bucks as you sip champagne on a balcony, or cozy up with your someone special and take in the classy artwork. Put that big marble tub to good use. The more fragrant bath salts, the merrier!

At Travelocity, we offer the vacation villa options you want, with a number of villas available for rent in Southeast Missouri. Get the most out of your time in this fascinating city, wise wanderer, and browse our available villas today.

Top Trending Hotels in Southeast Missouri

See all 161 Properties in Southeast Missouri
Pear Tree Inn Cape Girardeau West $63
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy, Cape Girardeau, MO
     
    2.5 out of 5.0 Stars

    Situated in a rural location, this hotel is 2.8 mi (4.5 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Shawnee National Forest and Isle Casino Cape Girardeau. Southeast Missouri State University and Cape Girardeau Conservation Nature Center are also within 6 mi (10 km).

    Auburn Place Hotel And Suites $69
    Auburn Place Hotel And Suites

    Auburn Place Hotel And Suites

    3265 William St, Cape Girardeau, MO
       
      2.5 out of 5.0 Stars

      Situated in Cape Girardeau, this hotel is 2.5 mi (4 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Shawnee National Forest and Isle Casino Cape Girardeau. Southeast Missouri State University and Cape Girardeau Conservation Nature Center are also within 6 mi (10 km).

      Drury Plaza Hotel Cape Girardeau Conference Center $99
      Drury Plaza Hotel Cape Girardeau Conference Center

      Drury Plaza Hotel Cape Girardeau Conference Center

      3351 Percy Drive, Cape Girardeau, MO
         
        3.0 out of 5.0 Stars

        Situated in Cape Girardeau, this hotel is 2.3 mi (3.7 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Isle Casino Cape Girardeau and Shawnee National Forest. Cape Girardeau Conservation Nature Center and Southeast Missouri State University are also within 6 mi (10 km).

        Pear Tree Inn Cape Girardeau Near the Medical Center $63
        Pear Tree Inn Cape Girardeau Near the Medical Center

        Pear Tree Inn Cape Girardeau Near the Medical Center

        3248 William St, Cape Girardeau, MO
           
          2.5 out of 5.0 Stars

          Located in the heart of Cape Girardeau, this hotel is 2.4 mi (3.9 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Isle Casino Cape Girardeau and Shawnee National Forest. Southeast Missouri State University and Cape Girardeau Conservation Nature Center are also within 6 mi (10 km).

          Popular Accommodation Searches

          *Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.