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Book Cheap Hotels in Southeast Missouri

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Tonight Dec 9 - Dec 10
This weekend Dec 13 - Dec 15
Next weekend Dec 20 - Dec 22

Most Frequently Booked Southeast Missouri Hotels

Price for 1 night 2 adults*

$63

Dec 13 - Dec 14

Per night/room

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5.0 103 Cape West Pkwy, Cape Girardeau, MO
4.2/5
(17 Reviews)
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A fitness center and a safe deposit box are also provided.
 
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$63

Dec 13 - Dec 14

Per night/room

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5.0 3248 William St, Cape Girardeau, MO
4.4/5
(25 Reviews)
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the express check-out. An outdoor pool and a safe deposit box are also provided.
 
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$99

Dec 15 - Dec 16

Per night/room

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 out of 5.0 3351 Percy Drive, Cape Girardeau, MO
4.7/5
(7 Reviews)
This hotel features an indoor pool, a 24-hour fitness center, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
 
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Top Cheap Southeast Missouri Hotel Deals

Price for 1 night 2 adults*

$64

Dec 15 - Dec 16

Per night/room

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2.0 out of 5.0 4101 Highway 67 N, Poplar Bluff, MO
4.5/5
(11 Reviews)
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are on offer.
 
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$79

Dec 10 - Dec 11

Per night/room

Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

2.5 out of 5.0 3265 William St, Cape Girardeau, MO
4.3/5
(16 Reviews)
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
 
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$72

Dec 13 - Dec 14

Per night/room

Pear Tree Inn - Sikeston

Pear Tree Inn - Sikeston

2.5 out of 5.0 2602 E Malone Avenue, Sikeston, MO
4.6/5
(24 Reviews)
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the fitness center and free perks like buffet breakfast and free self parking.
 
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Top Luxury Southeast Missouri Hotel Deals

Price for 1 night 2 adults*

$51

Dec 15 - Dec 16

Per night/room

Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2.0 out of 5.0 1711 Highway Z, Pevely, MO
2.8/5
(15 Reviews)
This motel features an indoor pool and a fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the spa tub and free perks like continental breakfast and free self parking.
 
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$64

Dec 15 - Dec 16

Per night/room

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2.0 out of 5.0 4101 Highway 67 N, Poplar Bluff, MO
4.5/5
(11 Reviews)
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are on offer.
 
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$56

Dec 15 - Dec 16

Per night/room

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2.0 out of 5.0 220 S Interstate Dr, Sikeston, MO
3.5/5
(13 Reviews)
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business center. There's a seasonal outdoor pool on site, and a 24-hour front desk and a garden are also provided.
 
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See all 162 Properties in Southeast Missouri
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How much is a hotel room in Southeast Missouri?

Hotels in Southeast Missouri start at $51 per night. Prices and availability subject to change. Additional terms may apply.

Cheap Hotels in Southeast Missouri

Pack your bags—it’s time to embark on a getaway. Whether you’re craving a solo retreat or promising your family a vacation to remember, book one of the best hotels in Southeast Missouri. These hotels are located within easy access of the city’s hottest attractions and entertainment, so you won’t miss a beat while you’re in town. Spend the days exploring the local landmarks and the evenings getting to know the nightlife. After exploring the city from top to bottom, rest up at a hotel that speaks to you. Find the perfect place that matches your trip’s vibe, from a trendy boutique to family-friendly accommodations.

Allow us here at Travelocity to pair you with up Southeast Missouri hotels that suit your vacation preferences. Discover places with convenient on-site restaurants, around-the-clock service, and pools where your kids can make a splash. Some hotels may boast fitness rooms and spa services, while others feature game rooms and Wi-Fi access. To top it all off, you’ll score cheap hotels in Southeast Missouri that let you spend more on your activities and less on your lodging. Book and bundle your flight and hotel deals together today and save up to $537. It’s time to explore a new city, and break out of your routine.

Recent Southeast Missouri Hotel Reviews By Fellow Wanderers

Pear Tree Inn Cape Girardeau West

4.0 Travelocity Verified Review
Rooms were lovely! Very clean and pretty amd spacious. LOVED the big bathroom.
5 days ago by A verified traveler
Open Pear Tree Inn Cape Girardeau West hotel guest reviews

Drury Inn & Suites Sikeston

5.0 Travelocity Verified Review
Nice place! It was clean and neat. Staff was efficient and friendly.
6 days ago by A verified traveler
Open Drury Inn & Suites Sikeston hotel guest reviews

Holiday Inn Poplar Bluff

4.0 Travelocity Verified Review
It didn’t have a Breakfast with your room purchase - it was always extra for everything. The restaurant in the building was alright but not great value for the money.
1 week ago by A verified traveler from Chanute
Open Holiday Inn Poplar Bluff hotel guest reviews

Auburn Place Hotel And Suites

5.0 Travelocity Verified Review
A fan in the rooms would be nice to block some of the noise from outside door.
2 weeks ago by A verified traveler
Open Auburn Place Hotel And Suites hotel guest reviews

Pear Tree Inn Cape Girardeau Near the Medical Center

5.0 Travelocity Verified Review
Room was clean and as advertised. Bed was comfortable, refrigerator could have been colder.
2 weeks ago by A verified traveler
Open Pear Tree Inn Cape Girardeau Near the Medical Center hotel guest reviews

Fairfield Inn & Suites by Marriott Poplar Bluff

5.0 Travelocity Verified Review
Very comfortable location and facility. Would stay again.
3 weeks ago by A verified traveler
Open Fairfield Inn & Suites by Marriott Poplar Bluff hotel guest reviews

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*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.