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Most frequently booked Southeast Missouri hotels

$100
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 out of 5.0 3351 Percy Drive, Cape Girardeau, MO
4.6/5
(9 Reviews)
This hotel features an indoor pool, a 24-hour fitness center, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
 
$65
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5.0 103 Cape West Pkwy, Cape Girardeau, MO
4.3/5
(21 Reviews)
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A fitness center and a safe deposit box are also provided.
 
$69
Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

2.5 out of 5.0 3265 William St, Cape Girardeau, MO
4.2/5
(16 Reviews)
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
 

Top cheap Southeast Missouri hotel deals

$65
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2.0 out of 5.0 4101 Highway 67 N, Poplar Bluff, MO
4.1/5
(14 Reviews)
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.
 
$69
Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

2.5 out of 5.0 3265 William St, Cape Girardeau, MO
4.2/5
(16 Reviews)
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the free buffet breakfast each morning.
 
$75
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5.0 2602 E Malone Avenue, Sikeston, MO
4.6/5
(26 Reviews)
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the fitness center and free daily breakfast.
 

Top luxury Southeast Missouri hotel deals

$51
Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2.0 out of 5.0 1711 Highway Z, Pevely, MO
2.8/5
(15 Reviews)
This motel features an indoor pool and a fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.
Reviewed on Oct 22, 2019

The desk clerk was friendly and helpful. The room was not clean, the floors (no carpeting) were not swept, the bathroom needed a good scrubbing, the hallway was not clean. Someone kept propping the back door (next to our room) open, even though there was a sign on the door stating it was locked and ...

 
$65
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2.0 out of 5.0 4101 Highway 67 N, Poplar Bluff, MO
4.1/5
(14 Reviews)
This motel doesn't skimp on freebies - guests receive free WiFi and free self parking. Luggage storage is provided and the front desk is staffed around-the-clock.
Reviewed on Jun 14, 2020

Was given a key to a room that was not even cleaned yet. A lot of suspicious activity going on with guests on the 3rd floor. People slammed doors all night. The most uncomfortable bed ever.

 
$65
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2.0 out of 5.0 220 S Interstate Dr, Sikeston, MO
3.5/5
(15 Reviews)
A health club, free self parking, and laundry facilities are featured at this hotel. WiFi in public areas is free. A library and luggage storage are also provided.
Reviewed on Feb 14, 2020

I didnt like that the front desk clerk was not smiling and that only one heater was in the room took a while for the rest of the room to get warm.And tje bathroom floor stayed cold

 
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How much is a hotel room in Southeast Missouri?

Hotels in Southeast Missouri start at $51 per night. Prices and availability subject to change. Additional terms may apply.

Cheap Hotels in Southeast Missouri

Pack your bags—it’s time to embark on a getaway. Whether you’re craving a solo retreat or promising your family a vacation to remember, book one of the best hotels in Southeast Missouri. These hotels are located within easy access of the city’s hottest attractions and entertainment, so you won’t miss a beat while you’re in town. Spend the days exploring the local landmarks and the evenings getting to know the nightlife. After exploring the city from top to bottom, rest up at a hotel that speaks to you. Find the perfect place that matches your trip’s vibe, from a trendy boutique to family-friendly accommodations.

Allow us here at Travelocity to pair you with up Southeast Missouri hotels that suit your vacation preferences. Discover places with convenient on-site restaurants, around-the-clock service, and pools where your kids can make a splash. Some hotels may boast fitness rooms and spa services, while others feature game rooms and Wi-Fi access. To top it all off, you’ll score cheap hotels in Southeast Missouri that let you spend more on your activities and less on your lodging. Book and bundle your flight and hotel deals together today and save up to $537. It’s time to explore a new city, and break out of your routine.


Recent Southeast Missouri hotel reviews by fellow wanderers


*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.