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Most Frequently Booked Southeast Missouri Hotels

$63
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5.0 103 Cape West Pkwy, Cape Girardeau, MO
4.2/5
(17 Reviews)
This hotel doesn't skimp on freebies - guests receive free buffet breakfast, free WiFi, and free self parking. Business travelers can take advantage of the 24-hour business center. A fitness center and a safe deposit box are also provided.
 
$63
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5.0 3248 William St, Cape Girardeau, MO
4.4/5
(25 Reviews)
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the express check-out. An outdoor pool and a safe deposit box are also provided.
 
$99
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 out of 5.0 3351 Percy Drive, Cape Girardeau, MO
4.7/5
(7 Reviews)
This hotel features an indoor pool, a 24-hour fitness center, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
 

Top Cheap Southeast Missouri Hotel Deals

$64
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2.0 out of 5.0 4101 Highway 67 N, Poplar Bluff, MO
4.5/5
(11 Reviews)
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are on offer.
 
$79
Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

2.5 out of 5.0 3265 William St, Cape Girardeau, MO
4.3/5
(16 Reviews)
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
 
$72
Pear Tree Inn - Sikeston

Pear Tree Inn - Sikeston

2.5 out of 5.0 2602 E Malone Avenue, Sikeston, MO
4.6/5
(24 Reviews)
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the fitness center and free perks like buffet breakfast and free self parking.
 

Top Luxury Southeast Missouri Hotel Deals

$51
Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2.0 out of 5.0 1711 Highway Z, Pevely, MO
2.8/5
(15 Reviews)
This motel features an indoor pool and a fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the spa tub and free perks like continental breakfast and free self parking.
 
$64
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2.0 out of 5.0 4101 Highway 67 N, Poplar Bluff, MO
4.5/5
(11 Reviews)
This hotel doesn't skimp on freebies - guests receive free WiFi and free self parking. The front desk is staffed around-the-clock and laundry facilities are on offer.
 
$56
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2.0 out of 5.0 220 S Interstate Dr, Sikeston, MO
3.5/5
(13 Reviews)
This hotel doesn't skimp on freebies - guests receive free continental breakfast, free WiFi, and free self parking. Business travelers can take advantage of the business center. There's a seasonal outdoor pool on site, and a 24-hour front desk and a garden are also provided.
 
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How much is a hotel room in Southeast Missouri?

Hotels in Southeast Missouri start at $51 per night. Prices and availability subject to change. Additional terms may apply.

Cheap Hotels in Southeast Missouri

Pack your bags—it’s time to embark on a getaway. Whether you’re craving a solo retreat or promising your family a vacation to remember, book one of the best hotels in Southeast Missouri. These hotels are located within easy access of the city’s hottest attractions and entertainment, so you won’t miss a beat while you’re in town. Spend the days exploring the local landmarks and the evenings getting to know the nightlife. After exploring the city from top to bottom, rest up at a hotel that speaks to you. Find the perfect place that matches your trip’s vibe, from a trendy boutique to family-friendly accommodations.

Allow us here at Travelocity to pair you with up Southeast Missouri hotels that suit your vacation preferences. Discover places with convenient on-site restaurants, around-the-clock service, and pools where your kids can make a splash. Some hotels may boast fitness rooms and spa services, while others feature game rooms and Wi-Fi access. To top it all off, you’ll score cheap hotels in Southeast Missouri that let you spend more on your activities and less on your lodging. Book and bundle your flight and hotel deals together today and save up to $537. It’s time to explore a new city, and break out of your routine.


Recent Southeast Missouri Hotel Reviews By Fellow Wanderers


*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.