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Top Southeast Missouri Spa Resorts & Hotels

$109
Holiday Inn Club Vacations Timber Creek Resort

Holiday Inn Club Vacations Timber Creek Resort

3.5 out of 5.0 4800 U.S. Highway 67, De Soto, MO
5/5
(1 Reviews)
This condo resort's 2 outdoor tennis courts and fitness center are among the featured amenities. There's fun for all ages with mini golf and a playground, and barbecue grills are available on site. Enjoy the seasonal outdoor pool and perks like free self parking and free WiFi.
$85
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 out of 5.0 3303 Campster Drive, Cape Girardeau, MO
4.9/5
(16 Reviews)
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
$93
Hampton Inn Farmington

Hampton Inn Farmington

2.5 out of 5.0 850 Valley Creek Dr, Farmington, MO
4.8/5
(4 Reviews)
This hotel features an indoor pool and a 24-hour fitness center. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
$99
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 out of 5.0 3351 Percy Drive, Cape Girardeau, MO
4.7/5
(7 Reviews)
This hotel features an indoor pool, a 24-hour fitness center, and a restaurant. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
$90
Drury Inn Poplar Bluff

Drury Inn Poplar Bluff

3.0 out of 5.0 2220 N Westwood Blvd, Poplar Bluff, MO
4.6/5
(5 Reviews)
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the fitness center and free perks like buffet breakfast and free self parking.
$81
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3.0 out of 5.0 1317 Highway 84, Hayti, MO
4.5/5
(17 Reviews)
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
$81
Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection

2.5 out of 5.0 4245 Hunt Rd, Farmington, MO
4.4/5
(5 Reviews)
A golf course and an indoor pool are featured at this smoke-free hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the outdoor tennis court and free perks like buffet breakfast and free self parking.
$81
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 out of 5.0 225 Drury Lane, Jackson, MO
4.4/5
(15 Reviews)
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
$69
Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

2.5 out of 5.0 3265 William St, Cape Girardeau, MO
4.3/5
(16 Reviews)
This hotel features an indoor pool and a fitness center. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. Enjoy the spa tub and free perks like buffet breakfast and free self parking.
$63
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2.0 out of 5.0 1119 Vincent Dr, Perryville, MO
4.2/5
(16 Reviews)
This motel features an indoor pool and a 24-hour fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the spa tub and free perks like continental breakfast and free self parking.
$51
Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2.0 out of 5.0 1711 Highway Z, Pevely, MO
2.8/5
(15 Reviews)
This motel features an indoor pool and a fitness center. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will appreciate freebies like continental breakfast and free self parking.
$52
Eagle Inn Charleston

Eagle Inn Charleston

2.0 out of 5.0 2811 East Marshall Street, Charleston, MO
A health club is featured at this motel, along with free self parking. WiFi in public areas is free. Staff at the 24-hour front desk can provide around-the-clock assistance.
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Southeast Missouri Spa Hotels

Are you looking for a break from the hustle and bustle of your day-to-day life? Do you want to escape reality and forget about your never ending to-do list? Then why not treat yourself to a relaxing stay at one of the spa hotels in Southeast Missouri? Whether it is for a weekend getaway or a staycation, book your visit to one of the Southeast Missouri luxury spa hotels.

With all of the amazing things to do around Southeast Missouri, you will likely be worn out from sightseeing. The Southeast Missouri spa hotels provide top of the line facilities with hot-tubs, saunas and private treatment rooms. Treat yourself to an indulgent hot stone massage or facial to rejuvenate from a busy day. If that's not enough for you, indulge in a full day-at-the-spa package. And maybe you are just looking to reach maximum relaxation before a fancy night out on the town. Take advantage of the salon features offered at most Southeast Missouri spa hotels and get a mani-pedi before your evening begins. 

Travelocity wants to help you relax and rejuvenate during your next stay in Southeast Missouri, but we know that spa treatments can put some strain on your wallet. Bundle your hotel and flight together and save enough to pay for your facial!

Recent Southeast Missouri Hotel Reviews By Fellow Wanderers

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.