Find & compare luxury hotels in Upstate South Carolina, SC

Seize Your Someday with our amazing deals for the whole family!

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Best Luxury Hotels in Upstate South Carolina

Hotel Hartness

Hotel Hartness

4 out of 5
120 Halston Avenue, Greenville, SC
Free Cancellation
Reserve now, pay when you stay
The price is $156 per night
$156
per night
May 19 - May 20
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and free perks like full breakfast and free self parking. There's a bar/lounge on site, and concierge services and wedding services are also provided.
Pet friendly
Breakfast included
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St, Clemson, SC
Free Cancellation
Reserve now, pay when you stay
The price is $169 per night
$169
per night
May 12 - May 13
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also offered.
Pet friendly
Breakfast available
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY, Greenville, SC
Free Cancellation
Reserve now, pay when you stay
The price is $332 per night
$332
per night
May 19 - May 20
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Relax with a drink at the bar/lounge and enjoy perks like free WiFi. Valet parking, a lobby fireplace, and a communal living room are also offered.
Pet friendly
Breakfast available
The Westin Poinsett Greenville

The Westin Poinsett Greenville

4 out of 5
120 South Main St, Greenville, SC
The price is $189 per night
$189
per night
Apr 28 - Apr 29
This hotel features a restaurant, a gym, and a bar/lounge. Traveling on business? Take advantage of the business center, free WiFi in public areas, and free airport shuttle. Valet parking, a coffee shop, and a grocery/convenience store are also offered.
Pet friendly
Breakfast available
Mint House Greenville - Downtown

Mint House Greenville - Downtown

4 out of 5
101 Falls Park Dr, Greenville, SC
The price is $139 per night
$139
per night
Apr 28 - Apr 29
A 24-hour gym is featured at this apartment, along with express check-in and laundry facilities.
Kitchen
Free WiFi
The Abernathy of Clemson

The Abernathy of Clemson

4 out of 5
157 Old Greenville Hwy, Clemson, SC
Free Cancellation
Reserve now, pay when you stay
The price is $149 per night
$149
per night
May 19 - May 20
A restaurant and a bar/lounge are featured at this hotel. Traveling on business? Take advantage of the business center and free WiFi in public areas. Free self parking, express check-in, and dry cleaning are also offered.
Pet friendly
Breakfast available
Greenville Marriott

Greenville Marriott

4 out of 5
1 Parkway E, Greer, SC
Free Cancellation
Reserve now, pay when you stay
The price is $101 per night
$101
per night
May 26 - May 27
This hotel features an outdoor pool, a 24-hour gym, and a restaurant. Traveling on business? Take advantage of the 24-hour business center, express check-in, and free airport shuttle. Relax with a drink at the bar/lounge and enjoy perks like free self parking.
Pet friendly
Breakfast available
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

4 out of 5
621 S Mechanic St, Pendleton, SC
The price is $122 per night
$122
per night
Apr 28 - Apr 29
This bed & breakfast features free WiFi in public areas, concierge services, and free self parking. Enjoy the free full breakfast each morning. A garden, express check-in, and express check-out are also on offer.
Breakfast included
Parking included
Hotel Domestique

Hotel Domestique

4 out of 5
10 Road of Vines, Travelers Rest, SC
The price is $469 per night
$469
per night
Apr 28 - Apr 29
This hotel features a restaurant, an outdoor tennis court, and a bar/lounge. Enjoy the seasonal outdoor pool and free perks like cooked-to-order breakfast and free self parking. Enjoy the sauna and conveniences like a 24-hour front desk and laundry facilities.
Pet friendly
Breakfast included
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Upstate South Carolina Luxury Hotels

Do you want to stay at an elegant 5 star hotel for your next getaway? Do you want to be pampered like royalty? When you're ready, the Upstate South Carolina luxury hotels are the plush oasis you’ve been looking for.

Choose from the best luxury hotels in Upstate South Carolina to make your stay as comfortable and memorable as possible. Deluxe amenities await you upon check-in—perks like a heated pool, luxurious spa, and 24-hour reception service will cater to your every need, no matter the hour. If you’re tired from the day’s activities and don’t feel like wandering around to look for a meal, sit down to dinner at one of the high-end restaurants on property or contact room service for a sophisticated dining experience in the comfort of your own suite. Getting to and from the airport will be an easy task as well because most of these fancy hotels offer a free shuttle service for easy transportation.

We want you to enjoy your next vacation in style and the top luxury resorts in Upstate South Carolina will help you do just that. Browse Travelocity right now to find amazing deals on the best luxury hotels and 4 star hotels in Upstate South Carolina, and plan your next opulent escape.


Upstate South Carolina hotels essential information

Accommodation
2,533 hotels
Lowest Price
$101
Highest Price
$469
Popular hotels
Hotel Hartness, The Shepherd Hotel Downtown Clemson, Grand Bohemian Lodge Greenville, Autograph Collection, The Westin Poinsett Greenville, Mint House Greenville - Downtown, The Abernathy of Clemson, Greenville Marriott, Liberty Hall Bed and Breakfast, Hotel Domestique

Seize your some day

Recent Upstate South Carolina Hotel Reviews By Fellow Wanderers

La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

5 out of 5
Posted 2 days ago
Travelocity Verified Review
"Great staff, clean, and comfortable. However, it could use a facelift."
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Greenville Haywood
La Quinta Inn & Suites by Wyndham Greenville Haywood

Explore more Luxury Hotels

Types of Hotels

Hotels Near...

Hotels By Star Rating

Areas Of Upstate South Carolina

Popular Luxury Hotel Destinations

Other Popular Luxury Accommodation