Cayo Guillermo Vacation Packages

Save when you book Cayo Guillermo package deals

Choose two or more items and save on your trip:

Flight and hotel packages to Cayo Guillermo

Price found within the past 48 hours. Click for updated prices.
Luxury Suites International At The Signature

Luxury Suites International At The Signature

4.5 out of 5
per person
Jul 13 - Jul 18
Roundtrip flight included
Dallas (DFW) to Las Vegas (LAS)
3 outdoor pools, a spa tub, and a gym are all featured at this luxury aparthotel. Traveling on business? Take advantage of the free WiFi in public areas and free valet parking. There's a restaurant and a bar/lounge for dining and drinks, and also a seasonal outdoor pool on site.
The Retreat Collection at 1 Hotel & Homes South Beach

The Retreat Collection at 1 Hotel & Homes South Beach

5 out of 5
South Beach
per person
Jul 16 - Jul 19
Roundtrip flight included
Dallas (DFW) to Miami (MIA)
This condo resort features 2 restaurants, 3 outdoor pools, and a gym. There's fun for all ages with a children's club and a children's pool, and babysitting is an added bonus. Enjoy the a rooftop terrace and perks like free WiFi.
1 Hotel South Beach

1 Hotel South Beach

5 out of 5
South Beach
per person
Jul 16 - Jul 19
Roundtrip flight included
Dallas (DFW) to Miami (MIA)
A full-service spa, 3 restaurants, and 3 outdoor pools are all featured at this smoke-free hotel. Relax with beach cabanas, sun loungers, and beach umbrellas. There's fun for all ages with a children's club and a children's pool, and in-room childcare is an added bonus.
Baglioni Hotel Regina - The Leading Hotels of the World

Baglioni Hotel Regina - The Leading Hotels of the World

5 out of 5
Rome City Centre
Save 100% on your flight
per person
Jul 24 - Jul 31
Roundtrip flight included
Chicago (ORD) to Rome (FCO)
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Families will appreciate the onsite laundry facilities and in-room childcare. Enjoy the sauna and perks like free WiFi.
Fairmont Miramar Bungalows

Fairmont Miramar Bungalows

5 out of 5
North of Wilshire
Save 100% on your flight
per person
Jun 23 - Jun 27
Roundtrip flight included
Dallas (DFW) to Los Angeles (LAX)
A full-service spa, a 24-hour gym, and a restaurant are all featured at this luxury hotel. Traveling on business? Take advantage of the business center, laundry service, and valet parking. Enjoy the outdoor pool and unwind at the bar/lounge and poolside bar.

Top Cayo Guillermo hotel deals

Hotel Grand Muthu Cayo Guillermo

Hotel Grand Muthu Cayo Guillermo

3.5 out of 5
Cayo Guillermo, Cayo Guillermo, Ciego de Avila
Get rates
A hair salon is available at this hotel.
Villa Gregorio

Villa Gregorio

2.5 out of 5
Carretera a Cayo Guillermo, Cayo Guillermo, Ciego de Avila
Get rates
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Relax with a drink at the poolside bar and enjoy free perks like continental breakfast and free self parking. A terrace, a garden, and a snack bar/deli are also on offer.
Iberostar Daiquirí - All inclusive

Iberostar Daiquirí - All inclusive

4 out of 5
Cayo Guillermo, Jardines del Rey, Moron Ciego de Avila, Cayo Guillermo, Ciego de Avila
Get rates
This all-inclusive property features 3 restaurants, 2 outdoor pools, and an outdoor tennis court. Enjoy a day at the beach snorkeling, or relax with beach umbrellas. Bring the family and enjoy the free kid's club, children's pool, and playground.
Club Cayo Guillermo - All Inclusive

Club Cayo Guillermo - All Inclusive

3.5 out of 5
Jardines del Rey, Cayo Guillermo, Ciego de Avila
Get rates
This all-inclusive property includes 3 restaurants, an outdoor pool, and a gym. Enjoy the sauna and free perks like buffet breakfast and free self parking. A bar/lounge, a 24-hour front desk, and a poolside bar are also provided.
Aparthotel Azul

Aparthotel Azul

2.5 out of 5
Carretera a Cayo Guillermo km 1 ½, Cayo Guillermo, Cayo Coco
Get rates
This hotel features a restaurant, an outdoor pool, and a bar/lounge. Free self parking, a coffee shop, and a garden are also offered.
Sitio La Guira

Sitio La Guira

2.5 out of 5
Carretera a Cayo Guillermo KM 1.5, Cayo Coco, Ciego de Avila
Get rates
The hotel doesn't skimp on freebies - guests receive free cooked-to-order breakfast and free self parking. A restaurant and a garden are also provided.
Don't see what you're looking for?
See all available properties in Cayo Guillermo
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit in Cayo Guillermo

Image for Cayo Guillermo Beach

Cayo Guillermo Beach

5/5(7 reviews)

Why not spend a carefree afternoon at Cayo Guillermo Beach during your travels in Cayo Guillermo? While you're in the area, wander around the natural setting.

Cayo Guillermo Beach
Image for Cayo Guillermo Marina

Cayo Guillermo Marina

4/5(2 reviews)

Cayo Guillermo Marina is just one of the places to see in Cayo Guillermo, so why not enjoy the other things to explore during your travels? While you're in the area, stroll along the white-sand beaches.

Cayo Guillermo Marina

Photos of local treasures

Cayo Guillermo

Frequently asked questions

How much are vacation packages to Cayo Guillermo?
Packages, including flights and hotels in Cayo Guillermo, start from $680. Make your daydreams a reality and lock in your trip with Travelocity today.
Where can I get the best vacation package deals for Cayo Guillermo?
Travelocity is the only place you need to go to score an incredible Cayo Guillermo package deal. Select from as many as 400 air carriers and 1,000,000 properties across the globe and craft a vacation package that’s right for you. With this amount of choice at your fingertips, you’ll have plenty of inspiration for your next big adventure.
Why should I book my Cayo Guillermo vacation bundle via Travelocity?
We’ve got 24/7 support, high-quality service and a Price Match Guarantee. Life’s a big journey — and we have alluring destinations for you to journey to all across the globe. Explore with us and your bank balance will thank you for it.
Can I save money on my Cayo Guillermo car rental if I book it with my hotel or flight?
You can with our Cayo Guillermo vacation packages. With one of these, there are plenty of ways to stretch your vacation budget further. Bundle any two or more car, flight, hotel and tour bookings and watch your savings pile up. With a rental car, all the attractions in and around Cayo Guillermo are just a road trip away.
What is the best time of year to go to Cayo Guillermo?
Pack your bags in and spend more of your money on memorable experiences, not your hotel room. This is the most inexpensive month to arrange your stay. Prices are at their highest in , so avoid traveling during this time if you want to save. February, March and April are the busiest months for Cayo Guillermo. You’ll need to book ahead of time and be prepared to pay premium rates. September, November and December are the quietest months.